Concept: This question tests your knowledge of the structural components of a neuron, specifically the distribution of Nissl's granules within different parts of the nerve cell.

Why (C) is correct: Nissl's granules (also known as Nissl bodies) are granular bodies found in the cytoplasm of neurons. They are composed of rough endoplasmic reticulum (RER) and free ribosomes, and their primary function is protein synthesis. They are abundant in the cell body (soma) and dendrites, where active protein synthesis is required for neuronal function and growth. However, they are conspicuously absent from the axon and its terminal branches, including the synaptic knobs (axon terminals). This absence reflects the fact that protein synthesis primarily occurs in the cell body and dendrites, with proteins then transported down the axon.

Why other options are wrong:

A) Cell body: Nissl's granules are abundant in the cell body.

B) Dendrites: Nissl's granules extend into the dendrites.

D) Both (1) and (2): This is incorrect because Nissl's granules are present in both the cell body and dendrites.

Common Mistake: Students often forget the specific distribution of organelles within different parts of a neuron, especially distinguishing between dendrites and axons regarding protein synthesis machinery.

NEET Tip / Mnemonic: Remember that Nissl's granules are like the 'protein factories' of the neuron, so they are found where most protein synthesis occurs – the cell body and dendrites. The axon and synaptic knob are primarily for transmission, not synthesis.

Correct Answer: (C)